Dr. Tsai, Hsin-Yue's Laboratory

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國立臺灣大學醫學院
分子醫學研究所
蔡欣祐老師實驗室
Ph.D. Tsai, Hsin-Yue.

Institute of Molecular Medicine, School of Medicine, National Taiwan University, 7 Chung Shan South Rd., Taipei, Taiwan, R.O.C.

Tel: 886-2-23123456 ext. 88588 (office) or 88589 (lab)
Fax: 886-2-23221675

Email: hsinyuetsai@ntu.edu.tw
 

 
 

Research Interest

我們實驗室主要在瞭解和探討核糖核酸(RNA)參與各式細胞分化的機制,及挖掘新的RNA調控的途徑。而其中我們尤其著眼於MCPIP (又名Regnase-1), 一個降解RNA的酵素,所參與的細胞分化機制。我們主要使用線蟲,巨噬細胞及內皮細胞做我們研究的對象,用生化,分生及遺傳的技術來了解MCPIP及其同源蛋白如何調控RNA的降解,進而影響細胞的分化。目前實驗室的四大方向為:

  1.  MCPIP 如何調控癌細胞相關之巨噬細胞(tumor associated macrophage)的轉變
    癌細胞相關之巨噬細胞是被癌細胞馴化的巨噬細胞,扮演著幫助癌細胞擴散的功能。先前的文獻中已證 實MCPIP尤其是降解RNA的能力在巨噬細胞被馴化的過程中扮演著重要的角色
  2. MCPIP 如何參與血管新生(Angiogenesis)的機制
    血管新生(Angiogenesis)是癌細胞獲得養分的主要方法,先前的文獻中指出MCPIP蛋白質的表現是促使血管新生的重要關鍵
  3. MCPIP在線蟲的同源蛋白之一如何影響線蟲精子的功能
    在探索MCPIP在線蟲的同源蛋白在線蟲的生長發育所扮演的腳色中,我們發現其中一個同源蛋白的基因變異造成線蟲的精子失去功能
  4. MCPIP 在線蟲的另一同源蛋白(REGE-1)如何影響線蟲脂肪的代謝和生成
    我們之前的發現和另一實驗室去年的發表指出線蟲的另一MCPIP同源蛋白 REGE-1會改變線蟲脂肪的含量,我們將探討REGE-1調控的RNA的機制

 

Our lab is interested in the mechanistic aspect of how RNA involves in various cell differentiation pathways, for instance macrophage polarization, angiogenesis stimulation, etc. and exploring new RNA players in these pathways. We also focus our search specifically on RNAs that are regulated by a ribonuclease named MCPIP1. The ribonuclease function of MCPIP1 (also named Regenase-1) is known critical for various cancer related processes including tumor associated macrophage polarization, angiogenesis in mammalian cells. We use C. elegans, macrophage cell lines, and endothelium cell lines as our model system to exploring how MCPIP and its homolog promoting cell differentiation. The projects in our lab including:

  1. How MCPIP promotes tumor associated macrophage polarization.
  2. How MCPIP promote angiogenesis in endothelium cell
  3. Why MCPIP C. elegans homolog protein is essential for spermatogenesis at elevated temperature
  4. How MCPIP C. elegans homolog protein is regulated in fat development in C. elegans

 

 

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