Dr. Hsu, Li-Chung's Laboratory

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國立臺灣大學醫學院
分子醫學研究所
徐立中老師實驗室
Ph.D. Hsu, Li-Chung

Institute of Molecular Medicine, School of Medicine, National Taiwan University, 7 Chung Shan South Rd., Taipei, Taiwan, R.O.C.

Tel: 886-2-23123456 #65700(office) #65703(laboratory)
 Fax: 886-2-23957801

Email: lichunghsu@ntu.edu.tw 

Last Update: 2014/07

 
 

Research Interest

Our lab is focused on understanding the regulation of the innate immune response against pathogenic infection and tissue damage. Innate immune system is the first line of host defense that prevents infection and eliminates the microbes. In addition, innate immunity plays a pivotal role in initiation and determination of the adaptive immune response. Innate immune cells, such as macrophages, use pattern-recognition receptors (PRRs) to detect conserved microbial molecules termed pathogen associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) released by injured cells to induce pro-inflammatory cytokines, chemokines, interferons and upregulate co-stimulatory molecules. Apart from the beneficial effects of pro-inflammatory cytokines in promoting inflammatory cell accumulation and stimulating the antimicrobial system, an imbalance between pro- and anti-inflammatory cytokines might contribute to the pathogenesis of chronic inflammatory and infectious disease. Thus, innate immune response must be tightly regulated to avoid uncontrolled inflammation.

We have been specifically interested in studying two types of PRRs: Toll-like receptors (TLRs) and the nucleotide-binding oligomerisation domain (NOD)-like receptors (NLRs). We utilize several approaches that include molecular and cellular studies, and mouse genetic model to address our research questions. Our current research interests are aimed at elucidating 1) the molecular mechanisms of TLR signaling pathways in activated macrophages, 2) the mechanism of the inflammasome activation and IL-1b production.
 

 

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